NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss.

@article{Lei2006NKX31SP,
  title={NKX3.1 stabilizes p53, inhibits AKT activation, and blocks prostate cancer initiation caused by PTEN loss.},
  author={Qunying Lei and Jing Jiao and L. T. Xin and Chun-Ju Chang and Shunyou Wang and Jing Gao and Martin E. Gleave and Owen N Witte and Xin Liu and Hong Wu},
  journal={Cancer cell},
  year={2006},
  volume={9 5},
  pages={367-78}
}
We demonstrate that PTEN loss causes reduced NKX3.1 expression in both murine and human prostate cancers. Restoration of Nkx3.1 expression in vivo in Pten null epithelium leads to decreased cell proliferation, increased cell death, and prevention of tumor initiation. Whereas androgen receptor (AR) positively regulates NKX3.1 expression, NKX3.1 negatively modulates AR transcription and consequently the AR-associated signaling events. Consistent with its tumor suppressor functions, NKX3.1 engages… CONTINUE READING

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salivary glands: parallels to glandular duct morphogenesis in prostate

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