NKT cell–mediated repression of tumor immunosurveillance by IL-13 and the IL-4R–STAT6 pathway

@article{Terabe2000NKTCR,
  title={NKT cell–mediated repression of tumor immunosurveillance by IL-13 and the IL-4R–STAT6 pathway},
  author={Masaki Terabe and So Matsui and Nancy Noben-Trauth and Hangjiong Chen and Cynthia J. Watson and Debra D. Donaldson and David Paul Carbone and W. Jack Christie Edwin J. Crossman Peter J. Doherty A Paul and Jay A. Berzofsky},
  journal={Nature Immunology},
  year={2000},
  volume={1},
  pages={515-520}
}
Using a mouse model in which tumors show a growth-regression-recurrence pattern, we investigated the mechanisms for down-regulation of cytotoxic T lymphocyte–mediated tumor immuno-surveillance. We found that interleukin 4 receptor (IL-4R) knockout and downstream signal transducer and activator of transcription 6 (STAT6) knockout, but not IL-4 knockout, mice resisted tumor recurrence, which implicated IL-13, the only other cytokine that uses the IL-4R–STAT6 pathway. We confirmed this by IL-13… CONTINUE READING
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A model for CD8+ CTL tumor immunosurveillance and regulation of tumor escape by CD4 T cells through an effect on quality of CTL

  • S Matsui
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  • 1999

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