NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells

@article{Upshaw2006NKG2DmediatedSR,
  title={NKG2D-mediated signaling requires a DAP10-bound Grb2-Vav1 intermediate and phosphatidylinositol-3-kinase in human natural killer cells},
  author={Jadee L. Upshaw and Laura N. Arneson and Renee A. Schoon and Christopher J. Dick and Daniel D Billadeau and Paul J. Leibson},
  journal={Nature Immunology},
  year={2006},
  volume={7},
  pages={524-532}
}
NKG2D is an important immunosurveillance receptor that responds to stress-induced ligand expression on tumors and virus-infected cells. Human natural killer cells express NKG2D and require the transmembrane adaptor DAP10 to initiate their full cytotoxic activation. However, DAP10 has no immunoreceptor tyrosine-based activation motif and thus the mechanism of recruiting 'downstream' effector proteins is unclear. We show here that binding of the p85 subunit of phosphatidylinositol-3- kinase to… CONTINUE READING

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Costimulation through NKG 2 D enhances murine CD 8 + CTL function : similarities and differences between NKG 2 D and CD 28 costimulation

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