NKG2D-mediated immunity underlying paroxysmal nocturnal haemoglobinuria and related bone marrow failure syndromes.

@article{Hanaoka2009NKG2DmediatedIU,
  title={NKG2D-mediated immunity underlying paroxysmal nocturnal haemoglobinuria and related bone marrow failure syndromes.},
  author={Nobuyoshi Hanaoka and Hideki Nakakuma and Kentaro Horikawa and Shoichi Nagakura and Yasuchika Tsuzuki and Masaya Shimanuki and Kensuke Kojima and Yuji Yonemura and Tatsuya Kawaguchi},
  journal={British journal of haematology},
  year={2009},
  volume={146 5},
  pages={538-45}
}
It is considered that a similar immune mechanism acts in the pathogenesis of bone marrow (BM) failure in paroxysmal nocturnal haemoglobinuria (PNH) and its related disorders, such as aplastic anaemia (AA) and myelodysplastic syndromes (MDS). However, the molecular events in immune-mediated marrow injury have not been elucidated. We recently reported an abnormal expression of stress-inducible NKG2D (natural-killer group 2, member D) ligands, such as ULBP (UL16-binding protein) and MICA/B (major… CONTINUE READING

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