NKCC1 Chloride Importer Antagonists Attenuate Many Neurological and Psychiatric Disorders

@article{BenAri2017NKCC1CI,
  title={NKCC1 Chloride Importer Antagonists Attenuate Many Neurological and Psychiatric Disorders},
  author={Yehezkel Ben-Ari},
  journal={Trends in Neurosciences},
  year={2017},
  volume={40},
  pages={536-554}
}
In physiological conditions, adult neurons have low intracellular Cl- [(Cl-)I] levels underlying the γ-aminobutyric acid (GABA)ergic inhibitory drive. In contrast, neurons have high (Cl-)I levels and excitatory GABA actions in a wide range of pathological conditions including spinal cord lesions, chronic pain, brain trauma, cerebrovascular infarcts, autism, Rett and Down syndrome, various types of epilepsies, and other genetic or environmental insults. The diuretic highly specific NKCC1… CONTINUE READING
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