NK cells suppress experimental cholestatic liver injury by an interleukin-6-mediated, Kupffer cell-dependent mechanism.

@article{Cheng2011NKCS,
  title={NK cells suppress experimental cholestatic liver injury by an interleukin-6-mediated, Kupffer cell-dependent mechanism.},
  author={Chao-Wen Cheng and Caroline C Duwaerts and Nico van Rooijen and Philip Wintermeyer and Stephanie Mott and Stephen H. Gregory},
  journal={Journal of hepatology},
  year={2011},
  volume={54 4},
  pages={746-52}
}
BACKGROUND & AIMS Natural killer (NK) cells are innate immune effector cells first characterized by their ability to lyse susceptible tumor cells. Recent studies demonstrated their role in initiating and modulating adaptive immunity. NK cells represent a larger percentage of the lymphoid population in liver than other organs, suggesting that hepatic NK cells express some unique function. Here, we examined the response of NK cells to liver injury that occurs in a mouse model of biliary… CONTINUE READING