NK cells stroll down the memory lane

@article{Pyzik2009NKCS,
  title={NK cells stroll down the memory lane},
  author={Michal Pyzik and Silvia M. Vidal},
  journal={Immunology and Cell Biology},
  year={2009},
  volume={87}
}
Antigen recognition, which leads to a stronger immune response upon re-challenge, has always been attributed to memory T and B cells. New evidence suggests that natural killer cells possess immunological memory providing enhanced protection to subsequent infections with the same pathogen. The crucial ability of our immune system to remember past encounters with a pathogen and elicit improved response to a secondary challenge provides long-term protection and makes vaccination possible. This… 
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References

SHOWING 1-10 OF 10 REFERENCES
Adaptive Immune Features of Natural Killer Cells
TLDR
A mouse model of cytomegalovirus infection is used to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000- fold in the liver after infection.
T cell– and B cell–independent adaptive immunity mediated by natural killer cells
TLDR
It is found that mice devoid of T cells and B cells demonstrated substantial contact hypersensitivity responses to 2,4-dinitrofluorobenzene and oxazolone, indicating that natural killer cells can mediate long-lived, antigen-specific adaptive recall responses independent of B cells and T cells.
Evolutionary struggles between NK cells and viruses
  • L. Lanier
  • Biology, Medicine
    Nature Reviews Immunology
  • 2008
TLDR
In addition to their participation in the immediate innate immune response against infection, interactions between NK cells and dendritic cells shape the nature of the subsequent adaptive immune response to pathogens.
Self-tolerance of natural killer cells
TLDR
The evidence for and against possible mechanisms of NK-cell self-tolerance are reviewed, with an emphasis on the role of MHC-specific receptors.
Licensing of natural killer cells by self‐major histocompatibility complex class I
TLDR
Recent studies suggest that NK cells undergo a host major histocompatibility complex (MHC) class I‐dependent functional maturation process, termed ‘licensing’, which results in two types of tolerant NK cells: functionally competent (licensed) NK cells, whose effector responses are inhibited by self‐MHC class I molecules through the same receptors that conferred licensing.
Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors
TLDR
Mouse cytomegalovirus encodes an MHC-like protein that binds to an inhibitory NK cell receptor in certain MCMV-susceptible mice, and this viral protein engages a related activating receptor and confers host protection.
Specific and nonspecific NK cell activation during virus infection
TLDR
It is shown that NK cell proliferation and production of interferon-γ (IFN-γ) was not dependent on Ly49H expression during early MCMV infection, however, during a later phase of infection, Ly 49H+ NK cells selectively proliferated and this expansion was blocked by anti-Ly49H administration.
Natural killer cell–directed therapies: moving from unexpected results to successful strategies
TLDR
Deeper investigation into the benefits of combination therapy, greater understanding of the functional distinctions between NK cell subsets, and design of new tools to monitor NK cell activity are needed to strengthen the ability to harness the power of NK cells for therapeutic aims.
Natural killer cell recognition of missing self
TLDR
Klas Karre recapitulates how the idea that NK cells can distinguish aberrant cells by recognizing 'absence of the expected', rather than 'pres presence of the unexpected' emerged, and the first five years of experimental work to test its general predictions.