NK cells stroll down the memory lane

  title={NK cells stroll down the memory lane},
  author={Michal Pyzik and Silvia M. Vidal},
  journal={Immunology and Cell Biology},
Antigen recognition, which leads to a stronger immune response upon re-challenge, has always been attributed to memory T and B cells. New evidence suggests that natural killer cells possess immunological memory providing enhanced protection to subsequent infections with the same pathogen. The crucial ability of our immune system to remember past encounters with a pathogen and elicit improved response to a secondary challenge provides long-term protection and makes vaccination possible. This… 
Natural Killer Cells in Hepatitis C Virus Infection
It is possible that an adequate NK cell response may control HCV infection, even in the absence of virus-specific immune responses, and is shown in animal models that depletion of NK cells before hepatotropic viral infection leads to inhibition of a virusspecific T cell response.
Natural killer cells: multifaceted players with key roles in hepatitis C immunity
In the setting of chronic HCV, overall NK cell levels are decreased, subset distribution is altered, and changes in NK receptor (NKR) expression have been demonstrated, although the contribution of individual NKRs to viral clearance or persistence remains to be clarified.
The interaction between CD300a and phosphatidylserine inhibits tumor cell killing by NK cells
A new tumor immune evasion mechanism that is mediated through the interaction between PS and CD300a is demonstrated and it is suggested that CD300c, similarly toCD300a, also interacts with PS.
Pathogenesis of Viral Respiratory Infection
The immunopathology vi‐ ral respiratory infection is a frequent consequence of the immune response against many of respiratory pathogens, and if the infection is established, the factors or viral viru‐ lence determinants and physiological conditions of the host cell will determine which direc‐ tion the infection will take.
NK cell metabolic adaptation to infection promotes survival and viral clearance
Upregulation of the metabolic adaptor hypoxia inducible factor-1 α (HIF-1α) is a feature of NK cells during murine cytomegalovirus infection in vivo, and HIF1α-deficient NK cells showed increased expression of the pro-apoptotic protein Bim and glucose metabolism was impaired during cytokine stimulation in vitro.
HIF1α is required for NK cell metabolic adaptation during virus infection
Upregulation of the metabolic adaptor hypoxia-inducible factor-1α (HIF1α) is a feature of mouse NK cells during murine cytomegalovirus infection in vivo, and HIF1 α-deficient NK cells showed increased expression of the pro-apoptotic protein Bim and glucose metabolism was impaired during cytokine stimulation in vitro.
Analysis of NK cells in intravenous drug users exposed to Hepatitis C
The phenotype and function of NK cells of IDUs with chronic HCV infection, resolvedHCV infection and seronegative IDUs are analyzed and a model in which HCV productively infects hepatocytes and causes type I interferon-mediated HLA-E upregulation is suggested.
Uncovering Mechanisms of Varicella Zoster Virus Pathogenesis Using a Rhesus Macaque Model
Analysis of the host-pathogen interactions in the lung and sensory ganglia as well as the role that T cells play in SVV tropism and reactivation revealed that SVV alters expression of several genes that may support viral replication and dissemination.
Procedimento Computacional para Simular o Efeito da Vacina no Sistema Imunológico Adaptativo Humano
Motivated by the need to discover cures or treatments for immunologic diseases, several computer science researches are being performed in the immune systems field. Those researches apply biology
Perfil de citocinas en mucosa nasal de pacientes pediátricos con infecciones respiratorias virales agudas.
En this estudio se incluyeron clento veintiun pacientes pediatricos con infeccion respiratoria aguda reclutados en el departamento de pediatria of the Universidad Autonoma de Nuevo Led.


Adaptive Immune Features of Natural Killer Cells
A mouse model of cytomegalovirus infection is used to show that, like T cells, NK cells bearing the virus-specific Ly49H receptor proliferate 100-fold in the spleen and 1,000- fold in the liver after infection.
T cell– and B cell–independent adaptive immunity mediated by natural killer cells
It is found that mice devoid of T cells and B cells demonstrated substantial contact hypersensitivity responses to 2,4-dinitrofluorobenzene and oxazolone, indicating that natural killer cells can mediate long-lived, antigen-specific adaptive recall responses independent of B cells and T cells.
Evolutionary struggles between NK cells and viruses
  • L. Lanier
  • Biology, Medicine
    Nature Reviews Immunology
  • 2008
In addition to their participation in the immediate innate immune response against infection, interactions between NK cells and dendritic cells shape the nature of the subsequent adaptive immune response to pathogens.
Self-tolerance of natural killer cells
The evidence for and against possible mechanisms of NK-cell self-tolerance are reviewed, with an emphasis on the role of MHC-specific receptors.
Licensing of natural killer cells by self‐major histocompatibility complex class I
Recent studies suggest that NK cells undergo a host major histocompatibility complex (MHC) class I‐dependent functional maturation process, termed ‘licensing’, which results in two types of tolerant NK cells: functionally competent (licensed) NK cells, whose effector responses are inhibited by self‐MHC class I molecules through the same receptors that conferred licensing.
Direct Recognition of Cytomegalovirus by Activating and Inhibitory NK Cell Receptors
Mouse cytomegalovirus encodes an MHC-like protein that binds to an inhibitory NK cell receptor in certain MCMV-susceptible mice, and this viral protein engages a related activating receptor and confers host protection.
Specific and nonspecific NK cell activation during virus infection
It is shown that NK cell proliferation and production of interferon-γ (IFN-γ) was not dependent on Ly49H expression during early MCMV infection, however, during a later phase of infection, Ly 49H+ NK cells selectively proliferated and this expansion was blocked by anti-Ly49H administration.
Natural killer cell–directed therapies: moving from unexpected results to successful strategies
Deeper investigation into the benefits of combination therapy, greater understanding of the functional distinctions between NK cell subsets, and design of new tools to monitor NK cell activity are needed to strengthen the ability to harness the power of NK cells for therapeutic aims.
Natural killer cell recognition of missing self
Klas Karre recapitulates how the idea that NK cells can distinguish aberrant cells by recognizing 'absence of the expected', rather than 'pres presence of the unexpected' emerged, and the first five years of experimental work to test its general predictions.