NK cells regulate CD8+ T cell effector function in response to an intracellular pathogen.

@article{Vankayalapati2004NKCR,
  title={NK cells regulate CD8+ T cell effector function in response to an intracellular pathogen.},
  author={Ramakrishna Vankayalapati and Peter Klucar and Benjamin Wizel and Stephen E. Weis and Buka Samten and Hassan Safi and Homayoun Shams and Peter F. Barnes},
  journal={Journal of immunology},
  year={2004},
  volume={172 1},
  pages={130-7}
}
We studied the role of NK cells in regulating human CD8+ T cell effector function against mononuclear phagocytes infected with the intracellular pathogen Mycobacterium tuberculosis. Depletion of NK cells from PBMC of healthy tuberculin reactors reduced the frequency of M. tuberculosis-responsive CD8+IFN-gamma+ cells and decreased their capacity to lyse M. tuberculosis-infected monocytes. The frequency of CD8+ IFN-gamma+ cells was restored by soluble factors produced by activated NK cells and… CONTINUE READING
73 Citations
0 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 73 extracted citations

Similar Papers

Loading similar papers…