NK cells link obesity-induced adipose stress to inflammation and insulin resistance

@article{Wensveen2015NKCL,
  title={NK cells link obesity-induced adipose stress to inflammation and insulin resistance},
  author={Felix M Wensveen and Vedrana Jelen{\vc}i{\'c} and Sonja Valenti{\'c} and Marko {\vS}estan and Tamara Turk Wensveen and Sebastian Theurich and Ariella Glasner and Davor Mendrila and Davor {\vS}timac and F Thomas Wunderlich and Jens C. Br{\"u}ning and Ofer Mandelboim and Bojan Poli{\'c}},
  journal={Nature Immunology},
  year={2015},
  volume={16},
  pages={376-385}
}
An important cause of obesity-induced insulin resistance is chronic systemic inflammation originating in visceral adipose tissue (VAT). VAT inflammation is associated with the accumulation of proinflammatory macrophages in adipose tissue, but the immunological signals that trigger their accumulation remain unknown. We found that a phenotypically distinct population of tissue-resident natural killer (NK) cells represented a crucial link between obesity-induced adipose stress and VAT inflammation… CONTINUE READING
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Proceedings of the National Academy of Sciences of the United States of America • 2013

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