NK cells kill mycobacteria directly by releasing perforin and granulysin.

  title={NK cells kill mycobacteria directly by releasing perforin and granulysin.},
  author={Chia-Chen Lu and T S Wu and Ya-Jing Hsu and Chih-Jung Chang and Chuan-Sheng Lin and J H Chia and T L Wu and Tsung-Teng Huang and J. C. Martel and David M. Ojcius and J. Young and H C Lai},
  journal={Journal of leukocyte biology},
  volume={96 6},
Although the mechanisms underlying the cytotoxic effect of NK cells on tumor cells and intracellular bacteria have been studied extensively, it remains unclear how these cells kill extracellular bacterial pathogens. In this study, we examine how human NK cells kill Mycobacterium kansasii and M.tb. The underlying mechanism is contact dependent and requires two cytolytic proteins: perforin and granulysin. Mycobacteria induce enhanced expression of the cytolytic proteins via activation of the… CONTINUE READING
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