NK cells in gamma-interferon-deficient mice suppress lung innate immunity against Mycoplasma spp.

@article{Woolard2005NKCI,
  title={NK cells in gamma-interferon-deficient mice suppress lung innate immunity against Mycoplasma spp.},
  author={Matthew D. Woolard and Dorothy Hudig and Leslie Tabor and James A Ivey and Jerry W. Simecka},
  journal={Infection and immunity},
  year={2005},
  volume={73 10},
  pages={6742-51}
}
The purpose of this study was to examine the 100-fold difference in mycoplasma levels in lungs of gamma interferon knockout (IFN-gamma(-/-)) mice compared to those seen with wild-type BALB/c mice at 3 days postinfection. NK cells secreted IFN-gamma; however, their cytotoxic granule extracts failed to kill mycoplasma. We found a conundrum: the clearance of organisms was as effective in NK-depleted IFN-gamma(-/-) animals as in wild-type mice (with both IFN-gamma and NK cells). NK(+) IFN-gamma… CONTINUE READING