NK cells gain higher IFN-γ competence during terminal differentiation.

@article{LuetkeEversloh2014NKCG,
  title={NK cells gain higher IFN-γ competence during terminal differentiation.},
  author={Merlin Verena Luetke-Eversloh and Basak B. Cicek and Francesco Siracusa and Jenny Tosca Thom and Alf Hamann and Stefan Frischbutter and Ria Baumgrass and Hyun-Dong Chang and Andreas Thiel and Jun Dong and Chiara Romagnani},
  journal={European journal of immunology},
  year={2014},
  volume={44 7},
  pages={2074-84}
}
NK cells are the main cells of the innate immune system that produce IFN-γ, and they express this cytokine at early stages of maturation in response to cytokine stimulation. Conversely, acquisition of IFN-γ-competence in CD4(+) T helper cells requires a differentiation process from naïve toward type 1 (Th1) cells, which is associated with epigenetic remodeling at the IFNG locus. In the present study, we show that the ability of NK cells to produce IFN-γ in response to activating receptor (actR… CONTINUE READING
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