NK cells engineered to express a GD2-specific antigen receptor display built-in ADCC-like activity against tumour cells of neuroectodermal origin

@inproceedings{Esser2012NKCE,
  title={NK cells engineered to express a GD2-specific antigen receptor display built-in ADCC-like activity against tumour cells of neuroectodermal origin},
  author={Ruth Esser and Tina Mueller and D{\"o}rthe Stefes and Stephan Kloess and Diana Seidel and Stephen D Gillies and Christel Aperlo-Iffland and James S. Huston and Christoph Uherek and Kurt Sch{\"o}nfeld and Torsten Tonn and Nicole Huebener and Holger N Lode and Ulrike Koehl and Winfried S. Wels},
  booktitle={Journal of cellular and molecular medicine},
  year={2012}
}
Treatment of high-risk neuroblastoma (NB) represents a major challenge in paediatric oncology. Alternative therapeutic strategies include antibodies targeting the disialoganglioside GD(2) , which is expressed at high levels on NB cells, and infusion of donor-derived natural killer (NK) cells. To combine specific antibody-mediated recognition of NB cells with the potent cytotoxic activity of NK cells, here we generated clonal derivatives of the clinically applicable human NK cell line NK-92 that… CONTINUE READING
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