NK cells after transplantation: friend or foe.

  title={NK cells after transplantation: friend or foe.},
  author={Uzi Hadad and Olivia M. Martinez and Sheri M. Krams},
  journal={Immunologic research},
  volume={58 2-3},
Natural killer (NK) cells are effector cells of the innate immune system that can lyse target cells without prior sensitization and have an important role in host defense to pathogens and transformed cells. A balance between negative and positive signals transmitted via germ line-encoded inhibitory and activating receptors controls the function of NK cells. Although the concept of "missing-self" would suggest that NK cells could target foreign allografts, the prevailing dogma has been that NK… CONTINUE READING
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