NK cells, hypoxia and trophoblast cell differentiation.

  title={NK cells, hypoxia and trophoblast cell differentiation.},
  author={Damayanti Chakraborty and Mohammad Azharul Karim Rumi and Michael J. Soares},
  journal={Cell cycle},
  volume={11 13},
Hemochorial placentation is characterized by extensive remodeling of the maternal vasculature, converting them to flaccid low resistance vessels. This process greatly facilitates exchange of nutrients and gases between the mother and the fetus. Two key modulators that orchestrate these vascular changes have been identified at the maternal fetal interface, natural killer (NK) cells and invasive trophoblast cells. Hypoxia-inducible factor (HIF) transcription factors direct cellular responses to… CONTINUE READING