NK cell survival mediated through the regulatory synapse with human DCs requires IL-15Ralpha.

@article{Brilot2007NKCS,
  title={NK cell survival mediated through the regulatory synapse with human DCs requires IL-15Ralpha.},
  author={Fabienne Brilot and Till Strowig and Susanne M. Roberts and Frida Arrey and Christian M{\"u}nz},
  journal={The Journal of clinical investigation},
  year={2007},
  volume={117 11},
  pages={3316-29}
}
DCs activate NK cells during innate immune responses to viral infections. However, the composition and kinetics of the immunological synapse mediating this interaction are largely unknown. Here, we report the rapid formation of an immunological synapse between human resting NK cells and mature DCs. Although inhibitory NK cell receptors were polarized to this synapse, where they are known to protect mature DCs from NK cell lysis, the NK cell also received activation signals that induced… CONTINUE READING