NK-cell reconstitution after haploidentical hematopoietic stem-cell transplantations: immaturity of NK cells and inhibitory effect of NKG2A override GvL effect.

@article{Nguyen2005NKcellRA,
  title={NK-cell reconstitution after haploidentical hematopoietic stem-cell transplantations: immaturity of NK cells and inhibitory effect of NKG2A override GvL effect.},
  author={Stephanie Nguyen and Nathalie Dh{\'e}din and Jean Paul Vernant and Mathieu Kuentz and Ahmad Al Jijakli and Nathalie Rouas-Freiss and Edgardo Delfino Carosella and Ali Boudifa and Patrice Debré and Vincent Vieillard},
  journal={Blood},
  year={2005},
  volume={105 10},
  pages={
          4135-42
        }
}
Natural killer (NK) cell alloreactivity is reported to mediate strong GvL (graft versus leukemia) effect in patients after haploidentical stem-cell transplantation (SCT) for acute myeloid leukemia (AML). Because subsequent immune reconstitution remains a major concern, we studied NK-cell recovery in 10 patients with AML who received haplomismatched SC transplants, among whom no GvL effect was observed, despite the mismatched immunoglobulin-like receptor (KIR) ligand in the GvH direction for 8… 

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