NK cell recognition of non-classical HLA class I molecules.

  title={NK cell recognition of non-classical HLA class I molecules.},
  author={Miguel L{\'o}pez-Botet and Manuel Llano and Francisco F Navarro and Teresa Bell{\'o}n},
  journal={Seminars in immunology},
  volume={12 2},
NK cells recognize several HLA class Ib molecules employing both immunoglobulin-like (Ig-like) and C-type lectin receptors. The CD94/NKG2 and NKG2D lectin-like molecules, respectively, interact with HLA-E and MICA; CD94/NKG2A functions as an inhibitory receptor, while CD94/NKG2C and NKG2D trigger NK cell activity. HLA-E predominantly presents nonamers from the leader sequences of other class I molecules; a peptide derived from HLA-G1 constitutes the highest affinity ligand for both CD94/NKG2… CONTINUE READING

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