NK cell receptors involved in the response to human cytomegalovirus infection.

@article{Gum2006NKCR,
  title={NK cell receptors involved in the response to human cytomegalovirus infection.},
  author={M{\'o}nica Gum{\'a} and Ana Angulo and Miguel L{\'o}pez-Botet},
  journal={Current topics in microbiology and immunology},
  year={2006},
  volume={298},
  pages={207-23}
}
Human cytomegalovirus (HCMV) infection is a paradigm of the complexity reached by host-pathogen interactions. To avoid recognition by cytotoxic T lymphocytes (CTL) HCMV inhibits the expression of HLA class I molecules. As a consequence, engagement of inhibitory killer immunoglobulin-like receptors (KIR), CD94/NKG2A, and CD85j (ILT2 or LIR-1) natural killer cell receptors (NKR) specific for HLA class I molecules is impaired, and infected cells become vulnerable to an NK cell response driven by… CONTINUE READING

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