NK cell education after allogeneic transplantation: dissociation between recovery of cytokine-producing and cytotoxic functions.

@article{Foley2011NKCE,
  title={NK cell education after allogeneic transplantation: dissociation between recovery of cytokine-producing and cytotoxic functions.},
  author={Bree Foley and Sarah Cooley and Michael R Verneris and Julie M. Curtsinger and Xianghua Luo and Edmund K Waller and Daniel J Weisdorf and Jeffrey S Miller},
  journal={Blood},
  year={2011},
  volume={118 10},
  pages={
          2784-92
        }
}
  • Bree Foley, Sarah Cooley, +5 authors Jeffrey S Miller
  • Published in Blood 2011
  • Medicine, Biology
  • Natural killer (NK) cells mediate GVL effects after allogeneic hematopoietic cell transplantation (allo-HCT) by the production of inflammatory cytokines and by direct target lysis. The acquisition of both functions was presumed to be developmentally linked, but this linkage remained unstudied after allo-HCT. We tested the cytokine production and degranulation of reconstituting NK cells after adult unrelated donor or umbilical cord blood grafting. Recipients of T cell-depleted transplants… CONTINUE READING

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