NK cell-derived interferon-γ orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infection.

@article{Goldszmid2012NKCI,
  title={NK cell-derived interferon-γ orchestrates cellular dynamics and the differentiation of monocytes into dendritic cells at the site of infection.},
  author={Romina S. Goldszmid and Pat Caspar and Aymeric Rivollier and Sandy L. White and Amiran H. Dzutsev and Sara Hieny and Brian Lee Kelsall and Giorgio Trinchieri and Alan Sher},
  journal={Immunity},
  year={2012},
  volume={36 6},
  pages={1047-59}
}
Dendritic cells (DCs), monocytes, and/or macrophages initiate host-protective immune responses to intracellular pathogens in part through interleukin-12 (IL-12) production, although the relative contribution of tissue resident versus recruited cells has been unclear. Here, we showed that after intraperitoneal infection with Toxoplasma gondii cysts, resident mononuclear phagocytes are replaced by circulating monocytes that differentiate in situ into inflammatory DCs (moDCs) and F4/80… CONTINUE READING