NK cell activating receptor ligand expression in lymphangioleiomyomatosis is associated with lung function decline.

@article{Osterburg2016NKCA,
  title={NK cell activating receptor ligand expression in lymphangioleiomyomatosis is associated with lung function decline.},
  author={Andrew Osterburg and Rebecca Louise Nelson and Benyamin Z Yaniv and Rachel Foot and Walter R F Donica and Madison A. Nashu and Huan Liu and Kathryn Wikenheiser-brokamp and Joel Moss and Nishant Gupta and Francis X McCormack and Michael T. Borchers},
  journal={JCI insight},
  year={2016},
  volume={1 16},
  pages={
          e87270
        }
}
Lymphangioleiomyomatosis (LAM) is a rare lung disease of women that leads to progressive cyst formation and accelerated loss of pulmonary function. Neoplastic smooth muscle cells from an unknown source metastasize to the lung and drive destructive remodeling. Given the role of NK cells in immune surveillance, we postulated that NK cell activating receptors and their cognate ligands are involved in LAM pathogenesis. We found that ligands for the NKG2D activating receptor UL-16 binding protein 2… CONTINUE READING

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