NK and T cell subsets regulate antibody production by human in vivo antigen-induced lymphoblastoid B cells.

@article{Brieva1984NKAT,
  title={NK and T cell subsets regulate antibody production by human in vivo antigen-induced lymphoblastoid B cells.},
  author={Jos{\'e} Antonio Brieva and Stephan Raoul Targan and Ronald H. Stevens},
  journal={Journal of immunology},
  year={1984},
  volume={132 2},
  pages={611-5}
}
This study demonstrates the existence of two different suppressive systems for the regulation of antitetanus toxoid antibody production by human lymphoblastoid (LB) B cells. These B cells appear in the circulation 5 to 7 days after in vivo immunization and spontaneously secrete antibody during a 3-day in vitro culture. One suppressive system was mediated by large granular lymphocytes that exhibited high natural killer activity. This suppressive cell subset spontaneously inhibited the antibody… CONTINUE READING

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