NK-active cytokines IL-2, IL-12, and IL-15 selectively modulate specific protein kinase C (PKC) isoforms in primary human NK cells.

@article{Vitale2002NKactiveCI,
  title={NK-active cytokines IL-2, IL-12, and IL-15 selectively modulate specific protein kinase C (PKC) isoforms in primary human NK cells.},
  author={Marco Vitale and Alessandra Bassini and Paola Secchiero and Prisco Mirandola and Cristina Ponti and Loris Zamai and Adriana R. Mariani and Mirella Falconi and Giacomo Azzali},
  journal={The Anatomical record},
  year={2002},
  volume={266 2},
  pages={87-92}
}
Natural killer (NK) cell function is largely modulated by growth factors and cytokines. In particular, interleukin (IL)-2, IL-12, and IL-15 have major effects on the proliferative and cytotoxic activities of NK cells against tumor and virus-infected cells. It is thought that the members of the protein kinase C (PKC) family of serine/threonine kinases play… CONTINUE READING