NK T cells provide lipid antigen-specific cognate help for B cells.

  title={NK T cells provide lipid antigen-specific cognate help for B cells.},
  author={Elizabeth A. Leadbetter and Manfred Brigl and Petr Illarionov and Nadia Cohen and Megan C Luteran and S. C. Pillai and Gurdyal S Besra and Michael B Brenner},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  volume={105 24},
The mechanisms of T cell help for production of antilipid antibodies are largely unknown. This study shows that invariant NK T cells (iNK T cells) and B cells cooperate in a model of antilipid antigen-specific antibody responses. We use a model haptenated lipid molecule, 4-hydroxy-3-nitrophenyl-alphaGalactosylCeramide (NP-alphaGalCer), to demonstrate that iNK T cells provide cognate help to lipid-antigen-presenting B cells. B cells proliferate and IgG anti-NP is produced from in vivo-immunized… CONTINUE READING
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