NK Cells and γδ T Cells Mediate Resistance to Polyomavirus–Induced Tumors

@inproceedings{Mishra2010NKCA,
  title={NK Cells and γδ T Cells Mediate Resistance to Polyomavirus–Induced Tumors},
  author={Rabinarayan Mishra and Alex T. Chen and Raymond M. Welsh and Eva Szomolanyi-Tsuda},
  booktitle={PLoS pathogens},
  year={2010}
}
NK and gammadelta T cells can eliminate tumor cells in many experimental models, but their effect on the development of tumors caused by virus infections in vivo is not known. Polyomavirus (PyV) induces tumors in neonatally infected mice of susceptible strains and in adult mice with certain immune deficiencies, and CD8+ alphabeta T cells are regarded as the main effectors in anti-tumor immunity. Here we report that adult TCRbeta knockout (KO) mice that lack alphabeta but have gammadelta T cells… CONTINUE READING

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