NK Cells Use Perforin Rather than Granulysin for Anticryptococcal Activity1

@article{Ma2004NKCU,
  title={NK Cells Use Perforin Rather than Granulysin for Anticryptococcal Activity1},
  author={L. Ma and Christopher L. C. Wang and G. Neely and S. Epelman and A. Krensky and C. Mody},
  journal={The Journal of Immunology},
  year={2004},
  volume={173},
  pages={3357 - 3365}
}
Cytotoxic lymphocytes have the capacity to kill microbes directly; however, the mechanisms involved are poorly understood. Using Cryptococcus neoformans, which causes a potentially fatal fungal infection in HIV-infected patients, our previous studies showed that granulysin is necessary, while perforin is dispensable, for CD8 T lymphocyte fungal killing. By contrast, the mechanisms by which NK cells exert their antimicrobial activity are not clear, and in particular, the contribution of… Expand
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Cytotoxic CD4+ T cells use granulysin to kill Cryptococcus neoformans, and activation of this pathway is defective in HIV patients.
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Perforin-Dependent Cryptococcal Microbicidal Activity in NK Cells Requires PI3K-Dependent ERK1/2 Signaling1
TLDR
A conserved PI3K-ERK1/2 pathway is identified that is used by NK cells during the direct killing of C. neoformans and it is demonstrated that the pathway is essential in the formation and activation of the microbicidal mechanism. Expand
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Cryptococcus Interactions with Innate Cytotoxic Lymphocytes
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