NK Cells Regulate CD8+ T Cell Priming and Dendritic Cell Migration during Influenza A Infection by IFN-γ and Perforin-Dependent Mechanisms

@article{Ge2012NKCR,
  title={NK Cells Regulate CD8+ T Cell Priming and Dendritic Cell Migration during Influenza A Infection by IFN-$\gamma$ and Perforin-Dependent Mechanisms},
  author={M. Ge and A. Ho and Y. Tang and K. H. Wong and B. Chua and S. Gasser and D. Kemeny},
  journal={The Journal of Immunology},
  year={2012},
  volume={189},
  pages={2099 - 2109}
}
An effective immune response against influenza A infection depends on the generation of virus-specific T cells. NK cells are one of the first-line defenses against influenza A infection. We set out to delineate the role of NK cells in T cell immunity using a murine model of influenza A infection with A/PR/8/34. We show that early T cell recruitment mainly occurs in the posterior mediastinal lymph node (pMLN). Depletion of NK cells significantly impaired both dendritic cell (DC) and T cell… Expand
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