NK-Cell Enteropathy and Similar Indolent Lymphoproliferative Disorders: A Case Series With Literature Review

@article{Xia2019NKCellEA,
  title={NK-Cell Enteropathy and Similar Indolent Lymphoproliferative Disorders: A Case Series With Literature Review},
  author={Daniel Xia and Elizabeth A. Morgan and David Berger and Geraldine S. Pinkus and Judith A. Ferry and Lawrence R. Zukerberg},
  journal={American Journal of Clinical Pathology},
  year={2019},
  volume={151},
  pages={75–85}
}
Objectives We report four new cases of natural killer-cell enteropathy (NKCE) and similar lymphoproliferative disorders (LPDs), as well as review the literature concerning indolent natural killer (NK)-cell LPDs of the gastrointestinal tract. Methods Pathologic and clinical data were obtained from institutional/referral records. Results Patient 1 (45-year-old man) had anemia; a small intestinal lesion was endoscopically biopsied. Patient 2 (65-year-old woman) had biliary colic, treated with… 
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Lymph node involvement by enteropathy-like indolent NK-cell proliferation
TLDR
A unique case of lymph node infiltration by such EBV-negative NK-cell proliferation fortuitously found during routine examination of a gallbladder resected for biliary lithiasis is described.
An Enteropathy-like Indolent NK-Cell Proliferation Presenting in the Female Genital Tract.
TLDR
This report reports a unique case where an indolent lymphoproliferative disorder with features that resemble NK-cell enteropathy is encountered for the first time outside the gastrointestinal tract, specifically in the female genitourinary tract.
Primary Gastrointestinal T-Cell Lymphoma and Indolent Lymphoproliferative Disorders: Practical Diagnostic and Treatment Approaches
Simple Summary It is challenging for pathologists to diagnose primary gastrointestinal T-cell neoplasms. Besides the rarity of the diseases, the small biopsy material makes it more difficult to…
T- and NK-cell lymphoproliferative disorders of the gastrointestinal tract: review and update.
TLDR
This review covers lymphoid proliferations of the GI tract, emphasising their salient clinicopathological features and genetic abnormalities and provides practical insights into resolving difficult differential diagnoses in daily surgical pathology practice.
Indolent T-Cell Lymphoproliferative Disorders of the Gastrointestinal Tract (iTLPD-GI): A Review
TLDR
A biomarker-based approach to the diagnosis is provided and the most common issues in differentiating iTLPD-GI from other neoplastic and non-neoplastic disorders are described.
Gastrointestinal T- and NK-cell lymphomas and indolent lymphoproliferative disorders.
TLDR
The salient clinical, histopathologic, immunophenotypic, and molecular characteristics of primary GI T/NK-cell lymphomas and LPDs are described in view of recent developments and the differential diagnostic considerations are discussed.
Natural Killer Cell Enteropathy With Extraintestinal Involvement: Presenting as Symptomatic Anemia
TLDR
This atypical entity in a young adult man presenting with vague upper gastrointestinal symptoms and anemia requiring blood transfusion is described, and the response to budesonide therapy points toward a possible low-grade autoimmune process.
Diagnostic approach to T- and NK-cell lymphoproliferative disorders in the gastrointestinal tract.
TLDR
In Asia and South America, it is not uncommon to see involvement of the gastrointestinal tract by EBV-associated extranodal NK/T cell lymphoma, nasal type, which must be distinguished from NK cell enteropathy and EBv-associated mucocutaneous ulcers.
Overview of Gastrointestinal Lymphoproliferative disorders✰.
TLDR
An overview of WHO classification of digestive tumors and World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissue is discussed focusing on the changes in the most recent WHO texts.
Genetic and phenotypic characterization of indolent T-cell lymphoproliferative disorders of the gastrointestinal tract
TLDR
Targeted next-generation sequencing and comprehensive immunophenotypic analysis of indolent T-cell lymphoproliferative disorders of the gastrointestinal tract provides insights into the pathogenetic bases of these diseases and confirms the heterogeneous nature ofThese diseases.
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References

SHOWING 1-10 OF 20 REFERENCES
An Enteropathy-like Indolent NK-Cell Proliferation Presenting in the Female Genital Tract.
TLDR
This report reports a unique case where an indolent lymphoproliferative disorder with features that resemble NK-cell enteropathy is encountered for the first time outside the gastrointestinal tract, specifically in the female genitourinary tract.
Indolent T-cell lymphoproliferative disease of the gastrointestinal tract.
TLDR
The name "indolent T-LPD of the GI tract" is proposed for these lesions that can easily be mistaken for intestinal peripheral T-cell lymphoma, and lead to aggressive therapy.
NK-cell enteropathy: a benign NK-cell lymphoproliferative disease mimicking intestinal lymphoma: clinicopathologic features and follow-up in a unique case series.
TLDR
The term "NK-cell enteropathy" is proposed for this syndrome of as yet unknown etiology that mimics intestinal and NK-/T-cell lymphomas on endoscopic biopsies and can result in erroneous diagnosis, leading to aggressive chemotherapy.
Lymphomatoidgastropathy mimicking extranodal NK/T cell lymphoma, nasal type: a case report.
TLDR
A case of H. pylori-positive lymphomatoid gastropathy with massive NK-cell proliferation is reported in a 57-year-old female, and the possibility of this benign entity should be considered, and excessive treatment should be carefully avoided.
Atypical NK-cell Proliferation of the Gastrointestinal Tract in a Patient With Antigliadin Antibodies but not Celiac Disease
We describe a unique case of atypical natural killer (NK)-cell proliferation likely related to gluten sensitivity, mimicking NK-cell lymphoma. The patient, a 32-year-old man, has had persistent…
A unique case of an indolent CD56-positive T-cell lymphoproliferative disorder of the gastrointestinal tract: a lesion potentially misdiagnosed as natural killer/T-cell lymphoma.
TLDR
It is confirmed that patients may rarely present with a CD56-positive NK/T-cell-like proliferation of the gastrointestinal tract, yet follow an indolent clinical course, and all pathologic features of enteropathy-associated T-cell lymphoma or NK/ T- cell lymphoma should be present before making this diagnosis and exposing the patient to toxic chemotherapy.
Benign Indolent CD56-Positive NK-Cell Lymphoproliferative Lesion Involving Gastrointestinal Tract in an Adolescent
TLDR
The first Korean case, as well as the first case in an adolescent, of NK-cell enteropathy is reported, and early recognition of this entity could be important for appropriate disease management.
A case of lymphomatoid gastropathy: An indolent CD56-positive atypical gastric lymphoid proliferation, mimicking aggressive NK/T cell lymphomas.
TLDR
The recurrence of lymphomatoid gastropathy is very rare and should be diagnosed carefully to distinguish it from the aggressive lymphoma.
Clinicopathologic Analysis of 6 Lymphomatoid Gastropathy Cases: Expanding the Disease Spectrum to CD4−CD8+ Cases
TLDR
6 cases of lymphomatoid gastropathy were analyzed by investigating the clinicopathologic, immunohistochemical, and molecular findings, and 2 cases showed previously unreported unique immunophenotypes of CD4−CD8+.
A case of lymphomatoid gastropathy: a self-limited pseudomalignant natural killer (NK)-cell proliferative disease mimicking NK/T-cell lymphomas
TLDR
A rare case of lymphomatoid gastropathy in a 71-year-old female is reported, it is important that endoscopists consider this rare entity in the differential diagnosis, and excessive treatment should be avoided.
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