NK-Cell Enteropathy and Similar Indolent Lymphoproliferative Disorders: A Case Series With Literature Review

@article{Xia2019NKCellEA,
  title={NK-Cell Enteropathy and Similar Indolent Lymphoproliferative Disorders: A Case Series With Literature Review},
  author={Daniel Xia and Elizabeth A. Morgan and David Berger and Geraldine S. Pinkus and Judith A. Ferry and Lawrence R. Zukerberg},
  journal={American Journal of Clinical Pathology},
  year={2019},
  volume={151},
  pages={75–85}
}
Objectives We report four new cases of natural killer-cell enteropathy (NKCE) and similar lymphoproliferative disorders (LPDs), as well as review the literature concerning indolent natural killer (NK)-cell LPDs of the gastrointestinal tract. Methods Pathologic and clinical data were obtained from institutional/referral records. Results Patient 1 (45-year-old man) had anemia; a small intestinal lesion was endoscopically biopsied. Patient 2 (65-year-old woman) had biliary colic, treated with… 
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Lymph node involvement by enteropathy-like indolent NK-cell proliferation

A unique case of lymph node infiltration by such EBV-negative NK-cell proliferation fortuitously found during routine examination of a gallbladder resected for biliary lithiasis is described.

An Enteropathy-like Indolent NK-Cell Proliferation Presenting in the Female Genital Tract.

This report reports a unique case where an indolent lymphoproliferative disorder with features that resemble NK-cell enteropathy is encountered for the first time outside the gastrointestinal tract, specifically in the female genitourinary tract.

Lymphomatoid gastropathy/NK-cell enteropathy involving the stomach and intestine

A link between the pathogenesis of LyGa/NKCE and H. pylori infection is suggested, which is typically observed in the small and large intestines in North America, whereas almost all cases in Japan occur locally in the stomach.

Primary Gastrointestinal T-Cell Lymphoma and Indolent Lymphoproliferative Disorders: Practical Diagnostic and Treatment Approaches

This review provides a cross-sectional comparison of histological findings and summarized up-to-date clinically relevant information including the treatment strategies as well as practical differential diagnosis based on thorough literature review of primary gastrointestinal T-cell neoplasms.

T- and NK-cell lymphoproliferative disorders of the gastrointestinal tract: review and update.

Indolent T-Cell Lymphoproliferative Disorders of the Gastrointestinal Tract (iTLPD-GI): A Review

A biomarker-based approach to the diagnosis is provided and the most common issues in differentiating iTLPD-GI from other neoplastic and non-neoplastic disorders are described.

Gastrointestinal T- and NK-cell lymphomas and indolent lymphoproliferative disorders.

The salient clinical, histopathologic, immunophenotypic, and molecular characteristics of primary GI T/NK-cell lymphomas and LPDs are described in view of recent developments and the differential diagnostic considerations are discussed.

Natural Killer Cell Enteropathy With Extraintestinal Involvement: Presenting as Symptomatic Anemia

This atypical entity in a young adult man presenting with vague upper gastrointestinal symptoms and anemia requiring blood transfusion is described, and the response to budesonide therapy points toward a possible low-grade autoimmune process.

Overview of Gastrointestinal Lymphoproliferative disorders✰.

An overview of WHO classification of digestive tumors and World Health Organization (WHO) classification of tumors of hematopoietic and lymphoid tissue is discussed focusing on the changes in the most recent WHO texts.

Cellular Origins and Pathogenesis of Gastrointestinal NK- and T-Cell Lymphoproliferative Disorders

The current state of knowledge about the main types of immune cells in the gastrointestinal mucosa and the processes by which they may transform into neoplasms are summarized.

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