NK Cell–Like Behavior of Vα14i NK T Cells during MCMV Infection

@article{Wesley2008NKCB,
  title={NK Cell–Like Behavior of Vα14i NK T Cells during MCMV Infection},
  author={Johnna D. Wesley and Marlowe S. Tessmer and Deanna Chaukos and Laurent Brossay},
  journal={PLoS Pathogens},
  year={2008},
  volume={4},
  pages={223 - 247}
}
Immunity to the murine cytomegalovirus (MCMV) is critically dependent on the innate response for initial containment of viral replication, resolution of active infection, and proper induction of the adaptive phase of the anti-viral response. In contrast to NK cells, the Valpha14 invariant natural killer T cell response to MCMV has not been examined. We found that Valpha14i NK T cells become activated and produce significant levels of IFN-gamma, but do not proliferate or produce IL-4 following… CONTINUE READING

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