NIX-mediated mitophagy regulate metabolic reprogramming in phagocytic cells during mycobacterial infection.

  title={NIX-mediated mitophagy regulate metabolic reprogramming in phagocytic cells during mycobacterial infection.},
  author={Ranjeet Singh Mahla and Akhilesh Kumar and Helena J. Tutill and Sreevidhya Tarakkad Krishnaji and Bharathwaj Sathyamoorthy and Mahdad Noursadeghi and Judith Breuer and Amit Kumar Pandey and Himanshu Kumar},
RNASeq analysis of PBMCs from treatment naïve TB patients and healthy controls revealed that M. tuberculosis (Mtb) infection dysregulates several metabolic pathways and upregulates BNIP3L/NIX receptor mediated mitophagy. Analysis of publicly available transcriptomic data from the NCBI-GEO database indicated that M. bovis (BCG) infection also induces similar rewiring of metabolic and mitophagy pathways. Mtb chronic infection and BCG in-vitro infection both downregulated oxidative phosphorylation… Expand
1 Citations
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  • Can Song, Feihong Huang, +5 authors Hong Niu
  • Medicine
  • International journal of biological macromolecules
  • 2021
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