NIX-mediated mitophagy regulate metabolic reprogramming in phagocytic cells during mycobacterial infection.

@article{Mahla2020NIXmediatedMR,
  title={NIX-mediated mitophagy regulate metabolic reprogramming in phagocytic cells during mycobacterial infection.},
  author={Ranjeet Singh Mahla and Akhilesh Kumar and Helena J. Tutill and Sreevidhya Tarakkad Krishnaji and Bharathwaj Sathyamoorthy and Mahdad Noursadeghi and Judith Breuer and Amit Kumar Pandey and Himanshu Kumar},
  journal={Tuberculosis},
  year={2020},
  volume={126},
  pages={
          102046
        }
}
RNASeq analysis of PBMCs from treatment naïve TB patients and healthy controls revealed that M. tuberculosis (Mtb) infection dysregulates several metabolic pathways and upregulates BNIP3L/NIX receptor mediated mitophagy. Analysis of publicly available transcriptomic data from the NCBI-GEO database indicated that M. bovis (BCG) infection also induces similar rewiring of metabolic and mitophagy pathways. Mtb chronic infection and BCG in-vitro infection both downregulated oxidative phosphorylation… Expand
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