NIPP1 maintains EZH2 phosphorylation and promoter occupancy at proliferation-related target genes

  title={NIPP1 maintains EZH2 phosphorylation and promoter occupancy at proliferation-related target genes},
  author={Nikki Minnebo and Janina G{\"o}rnemann and Nichole O’Connell and Nele Van Dessel and Rita Derua and Marit Willemijn Vermunt and Rebecca Page and Monique Beullens and Wolfgang Peti and Aleyde Van Eynde and Mathieu Bollen},
  booktitle={Nucleic acids research},
The histone methyltransferase EZH2 regulates cell proliferation and differentiation by silencing Polycomb group target genes. NIPP1, a nuclear regulator of serine/threonine protein phosphatase 1 (PP1), has been implicated in the regulation of EZH2 occupancy at target loci, but the underlying mechanism is not understood. Here, we demonstrate that the phosphorylation of EZH2 by cyclin-dependent kinases at Thr416 creates a docking site for the ForkHead-associated domain of NIPP1. Recruited NIPP1… CONTINUE READING
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