NIPA Defines an SCF-Type Mammalian E3 Ligase that Regulates Mitotic Entry

  title={NIPA Defines an SCF-Type Mammalian E3 Ligase that Regulates Mitotic Entry},
  author={Florian Bassermann and Christine von Klitzing and Silvia M{\"u}nch and R Bai and Hiroyuki Kawaguchi and Stephan W. Morris and Christian Peschel and Justus Duyster},
The regulated oscillation of protein expression is an essential mechanism of cell cycle control. The SCF class of E3 ubiquitin ligases is involved in this process by targeting cell cycle regulatory proteins for degradation by the proteasome, with the F-box subunit of the SCF specifically recruiting a given substrate to the SCF core. Here we identify NIPA (nuclear interaction partner of ALK) as a human F-box-containing protein that defines an SCF-type E3 ligase (SCF(NIPA)) controlling mitotic… CONTINUE READING

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Control of the SCF ( Skp 2 - Cks 1 ) ubiquitin ligase by the APC / C ( Cdh 1 ) ubiquitin ligase

  • T. Bashir, N. V. Dorrello, V. Amador, D. Guardavaccaro
  • Nature
  • 2004
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