NIPA Defines an SCF-Type Mammalian E3 Ligase that Regulates Mitotic Entry

@article{Bassermann2005NIPADA,
  title={NIPA Defines an SCF-Type Mammalian E3 Ligase that Regulates Mitotic Entry},
  author={Florian Bassermann and Christine von Klitzing and Silvia M{\"u}nch and Ren-Yuan Bai and Hiroyuki Kawaguchi and Stephan W. Morris and Christian Peschel and Justus Duyster},
  journal={Cell},
  year={2005},
  volume={122},
  pages={45-57}
}
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Multisite Phosphorylation of Nuclear Interaction Partner of ALK (NIPA) at G2/M Involves Cyclin B1/Cdk1*♦
TLDR
This work identifies the region of NIPA that mediates binding to its substrate cyclin B1 and specifies 2 new residues, Ser-359 and Ser-395, implicated in the phosphorylation process at G2/M within this region.
The ubiquitin proteasome system - implications for cell cycle control and the targeted treatment of cancer.
The SCF Complex Is Essential to Maintain Genome and Chromosome Stability
TLDR
The normal roles that various SCF complexes have in maintaining genome stability are described before discussing the impact that aberrant SCF complex expression and/or function have on cancer pathogenesis.
APC/CCdh1-Mediated Degradation of the F-Box Protein NIPA Is Regulated by Its Association with Skp1
TLDR
It is shown that phosphorylated NIPA is degraded in late mitosis in an APC/CCdh1-dependent manner, defining a novel mode of regulating APC/.C/C-mediated ubiquitination.
SCF-FBXO31 E3 Ligase Targets DNA Replication Factor Cdt1 for Proteolysis in the G2 Phase of Cell Cycle to Prevent Re-replication*
TLDR
The data present an additional pathway that contributes to the FBXO31 function as a tumor suppressor and is independent of the pathways previously described for Cdt1 proteolysis in S and G2 phase.
Mitotic Entry: A Matter of Oscillating Destruction
TLDR
Oscillating ubiquitination of nuclear cyclin B1 driven by the SCFNIPA complex contributes to the timing of mitotic entry in the mammalian cell cycle.
Regulation of cell cycle drivers by Cullin-RING ubiquitin ligases
TLDR
This review focuses on how CRLs target key proteins for degradation or otherwise alter their functions to control the progression over the various cell cycle phases leading to cell division and how the anaphase-promoting complex/cyclosome complex closely cooperate to govern efficient cell cycle progression.
PUL21a-Cyclin A2 Interaction is Required to Protect Human Cytomegalovirus-Infected Cells from the Deleterious Consequences of Mitotic Entry
TLDR
It is concluded that the Cyclin A2-binding function of pUL21a contributes to the maintenance of a cell cycle state conducive for the completion of the HCMV replication cycle.
Deregulated proteolysis by the F-box proteins SKP2 and β-TrCP: tipping the scales of cancer
TLDR
The functionality and biology of the F-box proteins, SKP2 (S-phase kinase-associated protein 2) and β-TrCP (β-transducin repeat-containing protein), are explored, which are emerging as important players in cancer biogenesis owing to the deregulated proteolysis of their substrates.
Mechanisms and function of substrate recruitment by F-box proteins
TLDR
The evolution of substrate recruitment by F-box proteins, the dysregulation of substrates in disease and potential avenues for F- box protein-directed disease therapies are focused on.
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