NIMA-related kinases defective in murine models of polycystic kidney diseases localize to primary cilia and centrosomes.

@article{Mahjoub2005NIMArelatedKD,
  title={NIMA-related kinases defective in murine models of polycystic kidney diseases localize to primary cilia and centrosomes.},
  author={Moe R Mahjoub and Melissa L. Trapp and Lynne M Quarmby},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2005},
  volume={16 12},
  pages={3485-9}
}
A key feature of the polycystic kidney diseases is aberrant cell proliferation, a consequence of dysfunctional ciliary signaling. The NIMA-related kinases (Nek) Nek1 and Nek8 carry the causal mutations of two of the eight established mouse models of polycystic kidneys. Nek proteins have roles in cell cycle and may contribute to coordinate regulation of cilia and cell-cycle progression. Herein is reported that in a mouse kidney epithelial cell line, mNek1 localizes to centrosomes in interphase… CONTINUE READING
51 Citations
26 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 51 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 26 references

Similar Papers

Loading similar papers…