NIK is a component of the EGF/heregulin receptor signaling complexes

  title={NIK is a component of the EGF/heregulin receptor signaling complexes},
  author={Danying Chen and Liang-Guo Xu and Lei Chen and Lixia Li and Zhonghe Zhai and Hong-Bing Shu},
Nuclear factor κB-inducing kinase (NIK) is a member of the MAP kinase kinase kinase family that was first identified as a component of the TNF-R1-induced NF-κB activation pathway (TNF, tumor necrosis factor; nuclear factor kappaB, NF-κB). Gene knockout study, however, suggests that NIK is dispensable for TNF-R1- but required for lymphotoxin-β receptor-induced NF-κB activation. A NIK kinase inactive mutant is a potent inhibitor of NF-κB activation triggered by various stimuli, suggesting that… CONTINUE READING


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