NIH-3 T 3 cells transformed by the EJ-ras oncogene exhibit reduced platelet-derived growth factor-mediated Ca ' ' mobilization ( ras / G proteins / phospholipase )

@inproceedings{BenjaminNIH3T3,
  title={NIH-3 T 3 cells transformed by the EJ-ras oncogene exhibit reduced platelet-derived growth factor-mediated Ca ' ' mobilization ( ras / G proteins / phospholipase )},
  author={Christopher W Benjamin and J. A. CONNORt and W. G. TARPLEYt and R R Gorman}
}
NIH-3T3 cells transformed by the EJ-ras oncogene synthesize only 10-15% as much inositol 1,4,5trisphosphate (InsP3) as control cells after stimulation with platelet-derived growth factor (PDGF). This is despite the fact that the basal (unstimulated) levels of InsP3 synthesized in control and EJ-ras-transformed cells are not significantly different. Using… CONTINUE READING