NI956/QGC006, a Potent Orally Active, Brain-Penetrating Aminopeptidase A Inhibitor for Treating Hypertension.

@article{Keck2019NI956QGC006AP,
  title={NI956/QGC006, a Potent Orally Active, Brain-Penetrating Aminopeptidase A Inhibitor for Treating Hypertension.},
  author={Mathilde Keck and Hugo de Almeida and Delphine Comp{\`e}re and Nicolas Inguimbert and Adrien Flahault and Fabrice Balavoine and Bernard Pierre Roques and Catherine Llorens-Cortes},
  journal={Hypertension},
  year={2019},
  volume={73 6},
  pages={
          1300-1307
        }
}
Brain renin-angiotensin system hyperactivity has been implicated in the development and maintenance of hypertension. We have shown that aminopeptidase A is involved in the formation of brain angiotensin III, which exerts tonic stimulatory control over blood pressure in hypertensive deoxycorticosterone acetate-salt rats and spontaneously hypertensive rats. We have also shown that injection of the specific and selective aminopeptidase A inhibitor, (3S)-3-amino-4-sulfanyl-butane-1-sulfonic acid… CONTINUE READING

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