NHS-MAS3: a bifunctional chelator alternative to NHS-MAG3.

@article{Chang1999NHSMAS3AB,
  title={NHS-MAS3: a bifunctional chelator alternative to NHS-MAG3.},
  author={F. Chang and T. Qu and M. Rusckowski and D. Hnatowich},
  journal={Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine},
  year={1999},
  volume={50 4},
  pages={
          723-32
        }
}
  • F. Chang, T. Qu, +1 author D. Hnatowich
  • Published 1999
  • Chemistry, Medicine
  • Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
This laboratory uses an N-hydroxysuccinimide derivative of S-acetylmercaptoacetyltriglycine (NHS-MAG3) to conjugate amines for subsequent labeling with 99mTc. However, the synthesis from triglycerine is general and not restricted to this tripeptide. We had earlier selected a small number of alternative tripeptides and synthesized the corresponding NHS derivatives. Each was then evaluated in a search for bifunctional chelators with properties superior to NHS-MAG3, such as lower serum protein… Expand
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