NHERF1 and CFTR restore tight junction organisation and function in cystic fibrosis airway epithelial cells: role of ezrin and the RhoA/ROCK pathway

@article{Castellani2012NHERF1AC,
  title={NHERF1 and CFTR restore tight junction organisation and function in cystic fibrosis airway epithelial cells: role of ezrin and the RhoA/ROCK pathway},
  author={Stefano Castellani and Lorenzo Guerra and Maria Favia and Sante Di Gioia and Valeria Casavola and Massimo Conese},
  journal={Laboratory Investigation},
  year={2012},
  volume={92},
  pages={1527-1540}
}
Tight junctions (TJs) restrict the transit of ions and molecules through the paracellular route and act as a barrier to regulate access of inflammatory cells into the airway lumen. The pathophysiology of cystic fibrosis (CF) lung disease is characterised by abnormal ion and fluid transport across the epithelium and polymorphonuclear (PMN) leukocyte-dominated inflammatory response. Na+/H+ exchanger regulatory factor 1 (NHERF1) is a protein involved in PKA-dependent activation of CFTR by… CONTINUE READING
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