NHERF-1 is required for renal adaptation to a low-phosphate diet.

  title={NHERF-1 is required for renal adaptation to a low-phosphate diet.},
  author={Edward J. Weinman and Anuradha Boddeti and Rochelle Cunningham and Michael Akom and Fengying Wang and Yu Wang and Jie A. Liu and Deborah Ann Steplock and Shirish S Shenolikar and James B. Wade},
  journal={American journal of physiology. Renal physiology},
  volume={285 6},
The sodium-dependent renal phosphate transporter (Npt2, Na-Pi IIa) is the major regulated phosphate transporter in the renal proximal convoluted tubule. Npt2 associates with a number of PDZ-containing proteins including Na+H+ exchanger regulatory factor-1 (NHERF-1). To determine whether NHERF-1 is involved in the acute regulation of phosphate transport, wild-type and NHERF-1 (-/-) mice were stabilized on a high-phosphate diet and then acutely changed to a low-phosphate diet. At 24 h after the… CONTINUE READING


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