NHEJ and Other Repair Factors in V ( D )

V(D)J recombination requires the formation and resolution of programmed DNA double-strand breaks (DSBs) to effect the gene rearrangements necessary for immunoglobulin and T cell receptor formation. Improper repair of DNA DSBs can lead to deleterious consequences for the cell, including loss of genetic information, cell death, and formation of chromosomal… (More)