NHE4 is critical for the renal handling of ammonia in rodents.

@article{Bourgeois2010NHE4IC,
  title={NHE4 is critical for the renal handling of ammonia in rodents.},
  author={Soline Bourgeois and Leonie Van Meer and Bharath Wootla and May Bloch-Faure and R{\'e}gine Chambrey and Gary E. Shull and Lara R. Gawenis and Pascal Houillier},
  journal={The Journal of clinical investigation},
  year={2010},
  volume={120 6},
  pages={1895-904}
}
Ammonia absorption by the medullary thick ascending limb of Henle's loop (MTALH) is thought to be a critical step in renal ammonia handling and excretion in urine, in which it is the main acid component. Basolateral Na+/H+ exchangers have been proposed to play a role in ammonia efflux out of MTALH cells, which express 2 exchanger isoforms: Na+/H+ exchanger 1 (NHE1) and NHE4. Here, we investigated the role of NHE4 in urinary acid excretion and found that NHE4-/- mice exhibited compensated… CONTINUE READING