NHE3 in an ancestral vertebrate: primary sequence, distribution, localization, and function in gills.

@article{Choe2005NHE3IA,
  title={NHE3 in an ancestral vertebrate: primary sequence, distribution, localization, and function in gills.},
  author={K. Choe and A. Kato and S. Hirose and C. Plata and A. Sindi{\'c} and M. Romero and J. Claiborne and D. H. Evans},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2005},
  volume={289 5},
  pages={
          R1520-34
        }
}
  • K. Choe, A. Kato, +5 authors D. H. Evans
  • Published 2005
  • Biology, Medicine
  • American journal of physiology. Regulatory, integrative and comparative physiology
In mammals, the Na+/H+ exchanger 3 (NHE3) is expressed with Na+/K+-ATPase in renal proximal tubules, where it secretes H+ and absorbs Na+ to maintain blood pH and volume. In elasmobranchs (sharks, skates, and stingrays), the gills are the dominant site of pH and osmoregulation. This study was conducted to determine whether epithelial NHE homologs exist in elasmobranchs and, if so, to localize their expression in gills and determine whether their expression is altered by environmental salinity… Expand
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