NHE1 mediates MDA-MB-231 cells invasion through the regulation of MT1-MMP.

@article{Lin2011NHE1MM,
  title={NHE1 mediates MDA-MB-231 cells invasion through the regulation of MT1-MMP.},
  author={Yani Lin and Guoqiang Chang and Jian You Wang and Weina Jin and Lihong Wang and Huawen Li and Li Ma and Qinghua Li and Tianxiang Pang},
  journal={Experimental cell research},
  year={2011},
  volume={317 14},
  pages={
          2031-40
        }
}
Na⁺/H⁺ exchanger 1 (NHE1), an important regulator of intracellular pH (pH(i)) and extracellular pH (pH(e)), has been shown to play a key role in breast cancer metastasis. However, the exact mechanism by which NHE1 mediates breast cancer metastasis is not yet well known. We showed here that inhibition of NHE1 activity, with specific inhibitor Cariporide, could suppress MDA-MB-231 cells invasion as well as the activity and expression of MT1-MMP. Overexpression of MT1-MMP resulted in a… CONTINUE READING
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