NH(2)-terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer.

@article{Molina2002NH2terminalTH,
  title={NH(2)-terminal truncated HER-2 protein but not full-length receptor is associated with nodal metastasis in human breast cancer.},
  author={Miguel {\'A}ngel Molina and Rosana S{\'a}ez and Elizabeth Ramsey and Mar{\'i}a-Jos{\'e} Garcia-Barchino and Federico Cuesta Rojo and Adam J Evans and J 1137 Albanell and Edward Keenan and A{\~n}a Lluch and Javier Garcia-conde and Jos{\'e} Baselga and G. Clinton},
  journal={Clinical cancer research : an official journal of the American Association for Cancer Research},
  year={2002},
  volume={8 2},
  pages={347-53}
}
BACKGROUND The full-length receptor p185HER-2 undergoes a metalloprotease-dependent cleavage producing a membrane-associated fragment (p95HER-2) in cultured breast cancer cells. P95HER-2 has potentially enhanced signaling activity, but its expression and role in human breast cancer is poorly characterized. PURPOSE The purpose of this project was to characterize the expression of p95HER-2 in primary breast cancers and nodal metastasis, and to study association with clinicopathological factors… CONTINUE READING
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