NGF withdrawal induces apoptosis in CESS B cell line through p38 MAPK activation and Bcl-2 phosphorylation.

@article{Rosini2000NGFWI,
  title={NGF withdrawal induces apoptosis in CESS B cell line through p38 MAPK activation and Bcl-2 phosphorylation.},
  author={Paolo Rosini and Giovanna De Chiara and Maria Lucibello and Enrico Garaci and Federico Cozzolino and Maria Gabriella Torcia},
  journal={Biochemical and biophysical research communications},
  year={2000},
  volume={278 3},
  pages={753-9}
}
The sIgG(+) lymphoblastoid B cell line CESS spontaneously produces a high amount of NGF and expresses both high affinity (p140(Trk-A)) and low affinity (p75(NTR)) NGF receptors. Blocking NGF signals with neutralizing antibodies or specific Trk-A inhibitors induces a rapid phosphorylation of antiapoptotic Bcl-2 protein, followed by caspase activation, and apoptotic death of CESS cells. Bcl-2 phosphorylation in several sites within a approximately 60 aa "loop" domain of protein is known to… CONTINUE READING

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