NGF modulates sympathetic innervation of lymphoid tissues.

  title={NGF modulates sympathetic innervation of lymphoid tissues.},
  author={Sonia L. Carlson and Kathryn M Albers and D J Beiting and Michelle A Parish and James M Conner and Brian M. Davis},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  volume={15 9},
Immune tissues are known to be innervated by the sympathetic nervous system, but little is known of what directs the innervation to specific tissue compartments. This report examines the sympathetic innervation of immune tissues in transgenic mice that overexpress nerve growth factor (NGF) in skin and other epithelial structures. NGF transgenic mice exhibited dramatic hyperinnervation in the splenic marginal zone, and the medulla and capsule of peripheral lymph nodes. In contrast, the… CONTINUE READING