NGF is essential for hippocampal plasticity and learning.

Abstract

Nerve growth factor (NGF) is produced in the hippocampus throughout life and is retrogradely trafficked to septal cholinergic neurons, providing a potential mechanism for modulating cholinergic inputs and, thereby, hippocampal plasticity. To explore NGF modulation of hippocampal plasticity and function, NGF levels were augmented or blocked in intact adult… (More)
DOI: 10.1523/JNEUROSCI.2594-09.2009

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