NGF enhances electrically induced pain, but not axon reflex sweating

@article{Obreja2011NGFEE,
  title={NGF enhances electrically induced pain, but not axon reflex sweating},
  author={Otilia Obreja and Olga Kluschina and Alexandra Mayer and Michael Hirth and Roman R Rukwied},
  journal={PAIN®},
  year={2011},
  volume={152},
  pages={1856-1863}
}
High-affinity receptors for nerve growth factor (NGF) are found on nociceptors and sympathetic efferents. NGF is known to sensitize nociceptors, increase innervation density, and fire frequency of sympathetic fibers. We explored axonal sensitization of afferent and efferent fibers following intracutaneous injection of NGF in human and pig skin. In humans, frequency-dependent (5, 20, 100 Hz) electrically induced pain was assessed 1, 3, 7, 21, and 49 days post injection. Sweat output was recorded… CONTINUE READING

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