NGF-conjugated iron oxide nanoparticles promote differentiation and outgrowth of PC12 cells.

@article{Marcus2015NGFconjugatedIO,
  title={NGF-conjugated iron oxide nanoparticles promote differentiation and outgrowth of PC12 cells.},
  author={Michal Marcus and Hadas Skaat and Noa Alon and Shlomo Margel and Orit Shefi},
  journal={Nanoscale},
  year={2015},
  volume={7 3},
  pages={1058-66}
}
The search for regenerative agents that promote neuronal differentiation and repair is of great importance. Nerve growth factor (NGF) which is an essential contributor to neuronal differentiation has shown high pharmacological potential for the treatment of central neurodegenerative diseases such as Alzheimer's and Parkinson's. However, growth factors undergo rapid degradation, leading to a short biological half-life. In our study, we describe a new nano-based approach to enhance the NGF… CONTINUE READING
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